How Long Does Percocet Stay In Your System?

Percocet is an opioid consisting of oxycodone and acetaminophen. It is a medication prescribed for moderate or severe pain management. 

With that in mind, Percocet can be habit-forming, and many people abuse this drug for its euphoric effects. The FDA classifies Percocet as a Schedule II drug, which means it has some acceptable medical use, but a high possibility for abuse.  Over time, this drug can result in a tolerance, which means you will need to take more of it to receive the desired effects. 

It’s important to understand Percocet and its half-life and interactions. This knowledge can help you or your loved ones if you are struggling with Percocet use. It may also reduce the risks of an overdose.

What Happens When You Use Percocet? 

Percocet can help alleviate symptoms associated with chronic or acute pain. In some cases, it promotes feelings of drowsiness or relaxation. Other side effects include:

  • Dizziness
  • Nausea or stomach problems
  • Vomiting 
  • Headaches or migraines
  • Confusion or disorientation

If someone misuses Percocet, they may experience the following symptoms:

  • Depression
  • Anxiety
  • Low blood pressure
  • Problems with breathing
  • Coordination problems
  • Mood swings
  • Flushing or sweating

How Long Does Percocet Stay in Your System?

Urine tests usually detect Percocet within 1-2 hours after taking a dose. The tests will show Percocet for about 48-96 hours after the last dose. Blood tests detect Percocet for only up to 24 hours, which is why they aren’t often used in addiction treatment settings. Hair follicles may show evidence of Percocet for up to 90 days. 

Keep in mind that there are no quick fixes for eliminating Percocet from your system. Many people benefit from a structured, medical detox. 

Detox helps you safely eliminate the drug from your body. It also provides a supportive and non-judgmental environment for managing cravings. Detox tends to be the first step of comprehensive substance abuse treatment. 

Click here to learn more about Percocet addiction.

What Is The Half-Life Of Percocet?

On average, Percocet has a half-life of 3.5 hours. A half-life refers to the amount of time it takes for half a dose of Percocet to leave someone’s system. However, it often takes many half-lives for you to eliminate the drug from your body completely.

That said, several factors may impact the drug’s half-life, including:

  • The severity of drug use (heavy, chronic users often experience longer drug half-lives)
  • Individual body weight, size, and medical health.
  • Co-occurring substance use.
  • Individual age (older age can result in slower half-lives).
  • Individual metabolism.

What Does Percocet Show up as on a Drug Test? 

Percocet will reveal a positive screen for opioids. If you are taking Percocet for prescription medical purposes, you must advise your treatment team ahead of time. Keep in mind that other drugs you take, including nicotine or some medications like antidepressants, will also show up on a drug test. 

What Are The Signs of an Overdose?

Overdosing on Percocet can quickly become a life-threatening concern. An overdose can occur if you take too much of one substance, and it overwhelms the body. As a result, your body starts to shut down. In some cases, this can result in death. 

People are at heightened risk for overdosing opioids, particularly if they use them intravenously, or if they combine them with other substances. The signs of an overdose include: 

  • A blueish or purplish skin color.
  • Cold skin that feels clammy to the touch.
  • Excessive sleepiness or a coma.
  • Fainting.
  • Slowed or stopped breathing and nonresponsiveness to others.
  • Limp or weak muscles
  • Weak or no heartbeat.

If you think someone is overdosing on opioids, it’s imperative to reach out for medical assistance immediately by calling 911. Time is critical. If you have naloxone on hand, use it. If not, first responders may be able to revive the overdose.

To learn more about signs of an overdose, click on the following link:

Final Thoughts

Percocet abuse is a serious concern. Even if you are medically prescribed to take this substance, it can become habit-forming. Some people progress from using Percocet to taking more potent opioids like heroin or fentanyl. This can become a vicious and devastating cycle.

Help is available. If you believe that you or someone you know suffers from addiction or dependence to Percocet, please contact one of our addiction specialists and call 866-578-7471. 


  1. I’m more concerned about it effects like Depression, Anxiety,Low blood pressure, Problems with breathing. This isn’t good at all so users need to avoid abusing it

  2. After reading, I feel about Percocet that this drug should be taken if it’s highly required. There should be an alternative to it instead.

  3. These articles are very informative at the very least. If I have one gripe the names are a tongue twister????Drugs are always dangerous, Abusing it is never a good idea,

  4. Anything becoming habits especially any form of drugs needed to be checked. The fact that you feel good just for few hours doesn’t make it a lasting solution. Dightbthe urge.

  5. This drugs actually works for some things in the body, when properly used at the same dosage. Using it wrongly is when is works adversely and affect the health

  6. From this post The tests will show Percocet for about 48-96 hours after the last dose. Blood tests detect Percocet for only up to 24 hours, which is why they aren’t often used in addiction treatment settings.

  7. This shows how a good prescription can help and how misusing can harm. Good to always follow the instructions.

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